The Resource 11[beta]-HSD2 activity in an equine distal limb and thoracic wound model, by Karissa Marie Ketzner, (electronic resource)

11[beta]-HSD2 activity in an equine distal limb and thoracic wound model, by Karissa Marie Ketzner, (electronic resource)

Label
11[beta]-HSD2 activity in an equine distal limb and thoracic wound model
Title
11[beta]-HSD2 activity in an equine distal limb and thoracic wound model
Statement of responsibility
by Karissa Marie Ketzner
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Healing of wounds located on the distal limbs of horses is often complicated by exuberant granulation tissue (EGT) causing a delay in wound epithelialization. Eleven [Beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2) has been implicated along with aldosterone in the formation of fibrosis in human cardiac patients and in equine endometrial fibrosis. The purpose of this study was to evaluate 11[beta]-HSD2 activity in the formation of EGT in an equine distal limb and thoracic wound model. Five (6 cm2) full-thickness wounds were created on the dorsolateral aspect of each metacaparus (one bandaged and one unbandaged) and the lateral thoracic wall of 6 adult horses. Wound samples were taken at weeks 0, 1, 2, 4, and 6 and were examined grossly and histologically. 11[beta]-HSD2 activity was assessed by a radiometric conversion assay. Unlike distal limb wounds, thoracic wounds contracted during the study. No difference was noted histologically between the distal limb wounds, while the thoracic wounds had more evidence of wound repair than distal limb wounds during weeks 2-4. No wounds developed EGT. 11[beta]-HSD2 activity was found in all wound samples. Thoracic and bandaged distal limb wounds had an initial decrease in 11[beta]-HSD2 activity. In unbandaged distal limb wounds, the 11[beta]-HSD2 activity did not decrease until week 6. This is evidence that 11[beta]-HSD2 plays a role in equine wound repair. Further defining its role may allow new treatments for the prevention of EGT
Cataloging source
MMU
http://library.link/vocab/creatorName
Ketzner, Karissa Marie
Degree
M.S.
Dissertation year
2009.
Granting institution
University of Missouri-Columbia
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
NLM call number
QP603.D4
http://library.link/vocab/relatedWorkOrContributorName
Wilson, David A.
http://library.link/vocab/subjectName
  • Horses
  • Granulation tissue
  • Wound healing
  • Dehydrogenases
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2
  • Horses
  • Granulation Tissue
Target audience
specialized
Label
11[beta]-HSD2 activity in an equine distal limb and thoracic wound model, by Karissa Marie Ketzner, (electronic resource)
Instantiates
Publication
Note
  • "December 2009"
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010)
  • Thesis advisor: David A. Wilson
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
496003679
Extent
1 online resource
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)496003679
Label
11[beta]-HSD2 activity in an equine distal limb and thoracic wound model, by Karissa Marie Ketzner, (electronic resource)
Publication
Note
  • "December 2009"
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010)
  • Thesis advisor: David A. Wilson
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
496003679
Extent
1 online resource
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Note
MU: Access is limited to the campuses of the University of Missouri.
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)496003679

Library Locations

    • Curtis Laws Wilson LibraryBorrow it
      400 West 14th Street, Rolla, MO, 65409, US
      37.955220 -91.772210
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