The Resource Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
Resource Information
The item Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.This item is available to borrow from 1 library branch.
Resource Information
The item Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.
This item is available to borrow from 1 library branch.
- Summary
- Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference
- Language
- eng
- Edition
- Second edition.
- Extent
- 1 online resource
- Note
- Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005
- Contents
-
- List of Contributors ; Preface ; 1 Factors that impact the developability of drug candidates / Chao Han and Binghe Wang ; 1.1. Challenges facing the pharmaceutical industry ; 1.2. Factors that Impact Developability ; 1.3. Commercial goal ; 1.3.1. The Chemistry Efforts ; 1.3.2. Biotechnology in the Discovery of Medicine ; 1.3.3. Target Validation in Animal Models ; 1.3.4. Pharmacokinetics and Drug Metabolism ; 1.3.5. Preparation for Pharmaceutical Products ; 1.3.6. Remarks on Developability ; 1.4. Drug Delivery Factors that Impact Developability ; References ; 2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery / Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan ; 2.1. Introduction ; 2.2. Physiological Barriers to Drug Delivery ; 2.2.1. Paracellular Pathway ; 2.2.2. Transcellular Pathway ; 2.3. Biochemical Barriers to Drug Delivery ; 2.3.1. Metabolizing Enzymes ; 2.3.2. Transporters and Efflux Pumps ; 2.4. Chemical Barriers to Drug Delivery ; 2.4.1. Hydrogen-Bonding Potential ; 2.4.2. Other Properties ; 2.5. Drug Modifications to Enhance Transport Across Biological Barriers ; 2.5.1. Prodrugs and Structural Modifications ; 2.5.2. Formulations ; 2.6. Conclusions ; References ; 3 Physicochemical Properties, Formulation, and Drug Delivery / Dewey H. Barich, Mark T. Zell, and Eric J. Munson ; 3.1. Introduction ; 3.2. Physicochemical Properties ; 3.2.1. Solubility ; 3.2.2. Stability ; 3.3. Formulations ; 3.3.1. Processing steps ; 3.3.2. Influence of physicochemical properties on drugs in formulations ; 3.3.3. Other issues ; 3.4. Drug Delivery ; 3.4.1. Duration of Release ; 3.4.2. Site of Administration ; 3.4.3. Methods of Administration ; 3.5. Conclusion ; References ; 4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development / Christine Xu ; 4.1. Introduction ; 4.2. Target bioavailability ; 4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics ; 4.4. Pharmacokinetics (PK)
- pharmacodynamics (PD) in drug discovery and development ; 4.5. Source of variability of drug response ; 4.6. Recent development and issues of bio-analytical methodology ; 4.7. Mechanistic PK-PD models ; 4.8. Summary ; References ; 5 The Role of Transporters in Drug Delivery and Excretion / Marilyn E. Morris and Xiaowen Guan ; 5.1. Introduction ; 5.2. Drug Transport in absorption and excretion. ; 5.2.1. Intestinal transport ; 5.2.2. Hepatic Transport ; 5.2.3. Renal Transport ; 5.2.4. Blood-brain barrier transport ; 5.3. ABC (ATP-binding cassette) transporter family ; 5.3.1. P-glycoprotein (ABCB1) ; 5.3.2. Multidrug Resistance-associated Proteins (ABCC) ; 5.3.3. Breast Cancer Resistance Protein (ABCG2) ; 5.3.4. Other ABC transporters ; 5.4. SLC (solute carrier) transporter family ; 5.4.1. Organic Anion Transporting Polypeptides (SLCO) ; 5.4.2. Organic Anion Transporters (SLC22A) ; 5.4.3. Organic Cation Transporters (SLC22) ; 5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A) ; 5.4.5. Monocarboxylate Transporters (SLC16 and SLC5) ; 5.4.6. Peptide Transporters (SLC15A) ; 5.4.7. Other SLC transporters ; 5.5. Conclusions ; References ; 6 Intracellular delivery and disposition of small molecular weight drugs / Jeffrey Krise ; 6.1 Introduction ; 6.2. The relationship between the intracellular distribution of a drug and its activity ; 6.3
- Isbn
- 9781118833322
- Label
- Drug delivery : principles and applications
- Title
- Drug delivery
- Title remainder
- principles and applications
- Statement of responsibility
- edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
- Language
- eng
- Summary
- Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference
- Cataloging source
- DLC
- Dewey number
- 615.1/9
- Index
- index present
- LC call number
- RS199.5
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
- QV 785
- http://library.link/vocab/relatedWorkOrContributorDate
- 1962-
- http://library.link/vocab/relatedWorkOrContributorName
-
- Wang, Binghe
- Hu, Longqin
- Siahaan, Teruna
- http://library.link/vocab/subjectName
-
- Drug delivery systems
- Pharmaceutical chemistry
- Drug Delivery Systems
- Dosage Forms
- Drug Administration Routes
- MEDICAL
- Drug delivery systems
- Pharmaceutical chemistry
- Label
- Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
- Note
- Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- List of Contributors ; Preface ; 1 Factors that impact the developability of drug candidates / Chao Han and Binghe Wang ; 1.1. Challenges facing the pharmaceutical industry ; 1.2. Factors that Impact Developability ; 1.3. Commercial goal ; 1.3.1. The Chemistry Efforts ; 1.3.2. Biotechnology in the Discovery of Medicine ; 1.3.3. Target Validation in Animal Models ; 1.3.4. Pharmacokinetics and Drug Metabolism ; 1.3.5. Preparation for Pharmaceutical Products ; 1.3.6. Remarks on Developability ; 1.4. Drug Delivery Factors that Impact Developability ; References ; 2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery / Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan ; 2.1. Introduction ; 2.2. Physiological Barriers to Drug Delivery ; 2.2.1. Paracellular Pathway ; 2.2.2. Transcellular Pathway ; 2.3. Biochemical Barriers to Drug Delivery ; 2.3.1. Metabolizing Enzymes ; 2.3.2. Transporters and Efflux Pumps ; 2.4. Chemical Barriers to Drug Delivery ; 2.4.1. Hydrogen-Bonding Potential ; 2.4.2. Other Properties ; 2.5. Drug Modifications to Enhance Transport Across Biological Barriers ; 2.5.1. Prodrugs and Structural Modifications ; 2.5.2. Formulations ; 2.6. Conclusions ; References ; 3 Physicochemical Properties, Formulation, and Drug Delivery / Dewey H. Barich, Mark T. Zell, and Eric J. Munson ; 3.1. Introduction ; 3.2. Physicochemical Properties ; 3.2.1. Solubility ; 3.2.2. Stability ; 3.3. Formulations ; 3.3.1. Processing steps ; 3.3.2. Influence of physicochemical properties on drugs in formulations ; 3.3.3. Other issues ; 3.4. Drug Delivery ; 3.4.1. Duration of Release ; 3.4.2. Site of Administration ; 3.4.3. Methods of Administration ; 3.5. Conclusion ; References ; 4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development / Christine Xu ; 4.1. Introduction ; 4.2. Target bioavailability ; 4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics ; 4.4. Pharmacokinetics (PK) -- pharmacodynamics (PD) in drug discovery and development ; 4.5. Source of variability of drug response ; 4.6. Recent development and issues of bio-analytical methodology ; 4.7. Mechanistic PK-PD models ; 4.8. Summary ; References ; 5 The Role of Transporters in Drug Delivery and Excretion / Marilyn E. Morris and Xiaowen Guan ; 5.1. Introduction ; 5.2. Drug Transport in absorption and excretion. ; 5.2.1. Intestinal transport ; 5.2.2. Hepatic Transport ; 5.2.3. Renal Transport ; 5.2.4. Blood-brain barrier transport ; 5.3. ABC (ATP-binding cassette) transporter family ; 5.3.1. P-glycoprotein (ABCB1) ; 5.3.2. Multidrug Resistance-associated Proteins (ABCC) ; 5.3.3. Breast Cancer Resistance Protein (ABCG2) ; 5.3.4. Other ABC transporters ; 5.4. SLC (solute carrier) transporter family ; 5.4.1. Organic Anion Transporting Polypeptides (SLCO) ; 5.4.2. Organic Anion Transporters (SLC22A) ; 5.4.3. Organic Cation Transporters (SLC22) ; 5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A) ; 5.4.5. Monocarboxylate Transporters (SLC16 and SLC5) ; 5.4.6. Peptide Transporters (SLC15A) ; 5.4.7. Other SLC transporters ; 5.5. Conclusions ; References ; 6 Intracellular delivery and disposition of small molecular weight drugs / Jeffrey Krise ; 6.1 Introduction ; 6.2. The relationship between the intracellular distribution of a drug and its activity ; 6.3
- Control code
- 926623506
- Edition
- Second edition.
- Extent
- 1 online resource
- Form of item
- online
- Isbn
- 9781118833322
- Lccn
- 2015041751
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- http://library.link/vocab/ext/overdrive/overdriveId
- 9781118833308
- Specific material designation
- remote
- System control number
- (OCoLC)926623506
- Label
- Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
- Note
- Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
- List of Contributors ; Preface ; 1 Factors that impact the developability of drug candidates / Chao Han and Binghe Wang ; 1.1. Challenges facing the pharmaceutical industry ; 1.2. Factors that Impact Developability ; 1.3. Commercial goal ; 1.3.1. The Chemistry Efforts ; 1.3.2. Biotechnology in the Discovery of Medicine ; 1.3.3. Target Validation in Animal Models ; 1.3.4. Pharmacokinetics and Drug Metabolism ; 1.3.5. Preparation for Pharmaceutical Products ; 1.3.6. Remarks on Developability ; 1.4. Drug Delivery Factors that Impact Developability ; References ; 2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery / Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan ; 2.1. Introduction ; 2.2. Physiological Barriers to Drug Delivery ; 2.2.1. Paracellular Pathway ; 2.2.2. Transcellular Pathway ; 2.3. Biochemical Barriers to Drug Delivery ; 2.3.1. Metabolizing Enzymes ; 2.3.2. Transporters and Efflux Pumps ; 2.4. Chemical Barriers to Drug Delivery ; 2.4.1. Hydrogen-Bonding Potential ; 2.4.2. Other Properties ; 2.5. Drug Modifications to Enhance Transport Across Biological Barriers ; 2.5.1. Prodrugs and Structural Modifications ; 2.5.2. Formulations ; 2.6. Conclusions ; References ; 3 Physicochemical Properties, Formulation, and Drug Delivery / Dewey H. Barich, Mark T. Zell, and Eric J. Munson ; 3.1. Introduction ; 3.2. Physicochemical Properties ; 3.2.1. Solubility ; 3.2.2. Stability ; 3.3. Formulations ; 3.3.1. Processing steps ; 3.3.2. Influence of physicochemical properties on drugs in formulations ; 3.3.3. Other issues ; 3.4. Drug Delivery ; 3.4.1. Duration of Release ; 3.4.2. Site of Administration ; 3.4.3. Methods of Administration ; 3.5. Conclusion ; References ; 4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development / Christine Xu ; 4.1. Introduction ; 4.2. Target bioavailability ; 4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics ; 4.4. Pharmacokinetics (PK) -- pharmacodynamics (PD) in drug discovery and development ; 4.5. Source of variability of drug response ; 4.6. Recent development and issues of bio-analytical methodology ; 4.7. Mechanistic PK-PD models ; 4.8. Summary ; References ; 5 The Role of Transporters in Drug Delivery and Excretion / Marilyn E. Morris and Xiaowen Guan ; 5.1. Introduction ; 5.2. Drug Transport in absorption and excretion. ; 5.2.1. Intestinal transport ; 5.2.2. Hepatic Transport ; 5.2.3. Renal Transport ; 5.2.4. Blood-brain barrier transport ; 5.3. ABC (ATP-binding cassette) transporter family ; 5.3.1. P-glycoprotein (ABCB1) ; 5.3.2. Multidrug Resistance-associated Proteins (ABCC) ; 5.3.3. Breast Cancer Resistance Protein (ABCG2) ; 5.3.4. Other ABC transporters ; 5.4. SLC (solute carrier) transporter family ; 5.4.1. Organic Anion Transporting Polypeptides (SLCO) ; 5.4.2. Organic Anion Transporters (SLC22A) ; 5.4.3. Organic Cation Transporters (SLC22) ; 5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A) ; 5.4.5. Monocarboxylate Transporters (SLC16 and SLC5) ; 5.4.6. Peptide Transporters (SLC15A) ; 5.4.7. Other SLC transporters ; 5.5. Conclusions ; References ; 6 Intracellular delivery and disposition of small molecular weight drugs / Jeffrey Krise ; 6.1 Introduction ; 6.2. The relationship between the intracellular distribution of a drug and its activity ; 6.3
- Control code
- 926623506
- Edition
- Second edition.
- Extent
- 1 online resource
- Form of item
- online
- Isbn
- 9781118833322
- Lccn
- 2015041751
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- http://library.link/vocab/ext/overdrive/overdriveId
- 9781118833308
- Specific material designation
- remote
- System control number
- (OCoLC)926623506
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