Coverart for item
The Resource Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan

Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan

Label
Drug delivery : principles and applications
Title
Drug delivery
Title remainder
principles and applications
Statement of responsibility
edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
Contributor
Editor
Subject
Language
eng
Summary
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference
Member of
Cataloging source
DLC
Dewey number
615.1/9
Index
index present
LC call number
RS199.5
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
QV 785
http://library.link/vocab/relatedWorkOrContributorDate
1962-
http://library.link/vocab/relatedWorkOrContributorName
  • Wang, Binghe
  • Hu, Longqin
  • Siahaan, Teruna
http://library.link/vocab/subjectName
  • Drug delivery systems
  • Pharmaceutical chemistry
  • Drug Delivery Systems
  • Dosage Forms
  • Drug Administration Routes
  • MEDICAL
  • Drug delivery systems
  • Pharmaceutical chemistry
Label
Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
Instantiates
Publication
Note
Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
List of Contributors ; Preface ; 1 Factors that impact the developability of drug candidates / Chao Han and Binghe Wang ; 1.1. Challenges facing the pharmaceutical industry ; 1.2. Factors that Impact Developability ; 1.3. Commercial goal ; 1.3.1. The Chemistry Efforts ; 1.3.2. Biotechnology in the Discovery of Medicine ; 1.3.3. Target Validation in Animal Models ; 1.3.4. Pharmacokinetics and Drug Metabolism ; 1.3.5. Preparation for Pharmaceutical Products ; 1.3.6. Remarks on Developability ; 1.4. Drug Delivery Factors that Impact Developability ; References ; 2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery / Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan ; 2.1. Introduction ; 2.2. Physiological Barriers to Drug Delivery ; 2.2.1. Paracellular Pathway ; 2.2.2. Transcellular Pathway ; 2.3. Biochemical Barriers to Drug Delivery ; 2.3.1. Metabolizing Enzymes ; 2.3.2. Transporters and Efflux Pumps ; 2.4. Chemical Barriers to Drug Delivery ; 2.4.1. Hydrogen-Bonding Potential ; 2.4.2. Other Properties ; 2.5. Drug Modifications to Enhance Transport Across Biological Barriers ; 2.5.1. Prodrugs and Structural Modifications ; 2.5.2. Formulations ; 2.6. Conclusions ; References ; 3 Physicochemical Properties, Formulation, and Drug Delivery / Dewey H. Barich, Mark T. Zell, and Eric J. Munson ; 3.1. Introduction ; 3.2. Physicochemical Properties ; 3.2.1. Solubility ; 3.2.2. Stability ; 3.3. Formulations ; 3.3.1. Processing steps ; 3.3.2. Influence of physicochemical properties on drugs in formulations ; 3.3.3. Other issues ; 3.4. Drug Delivery ; 3.4.1. Duration of Release ; 3.4.2. Site of Administration ; 3.4.3. Methods of Administration ; 3.5. Conclusion ; References ; 4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development / Christine Xu ; 4.1. Introduction ; 4.2. Target bioavailability ; 4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics ; 4.4. Pharmacokinetics (PK) -- pharmacodynamics (PD) in drug discovery and development ; 4.5. Source of variability of drug response ; 4.6. Recent development and issues of bio-analytical methodology ; 4.7. Mechanistic PK-PD models ; 4.8. Summary ; References ; 5 The Role of Transporters in Drug Delivery and Excretion / Marilyn E. Morris and Xiaowen Guan ; 5.1. Introduction ; 5.2. Drug Transport in absorption and excretion. ; 5.2.1. Intestinal transport ; 5.2.2. Hepatic Transport ; 5.2.3. Renal Transport ; 5.2.4. Blood-brain barrier transport ; 5.3. ABC (ATP-binding cassette) transporter family ; 5.3.1. P-glycoprotein (ABCB1) ; 5.3.2. Multidrug Resistance-associated Proteins (ABCC) ; 5.3.3. Breast Cancer Resistance Protein (ABCG2) ; 5.3.4. Other ABC transporters ; 5.4. SLC (solute carrier) transporter family ; 5.4.1. Organic Anion Transporting Polypeptides (SLCO) ; 5.4.2. Organic Anion Transporters (SLC22A) ; 5.4.3. Organic Cation Transporters (SLC22) ; 5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A) ; 5.4.5. Monocarboxylate Transporters (SLC16 and SLC5) ; 5.4.6. Peptide Transporters (SLC15A) ; 5.4.7. Other SLC transporters ; 5.5. Conclusions ; References ; 6 Intracellular delivery and disposition of small molecular weight drugs / Jeffrey Krise ; 6.1 Introduction ; 6.2. The relationship between the intracellular distribution of a drug and its activity ; 6.3
Control code
926623506
Edition
Second edition.
Extent
1 online resource
Form of item
online
Isbn
9781118833322
Lccn
2015041751
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
http://library.link/vocab/ext/overdrive/overdriveId
9781118833308
Specific material designation
remote
System control number
(OCoLC)926623506
Label
Drug delivery : principles and applications, edited by Binghe Wang, Longqin Hu, Teruna J. Siahaan
Publication
Note
Revision of: Drug delivery / Binghe Wang, Teruna Siahaan, Richard Soltero. 2005
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
List of Contributors ; Preface ; 1 Factors that impact the developability of drug candidates / Chao Han and Binghe Wang ; 1.1. Challenges facing the pharmaceutical industry ; 1.2. Factors that Impact Developability ; 1.3. Commercial goal ; 1.3.1. The Chemistry Efforts ; 1.3.2. Biotechnology in the Discovery of Medicine ; 1.3.3. Target Validation in Animal Models ; 1.3.4. Pharmacokinetics and Drug Metabolism ; 1.3.5. Preparation for Pharmaceutical Products ; 1.3.6. Remarks on Developability ; 1.4. Drug Delivery Factors that Impact Developability ; References ; 2. Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery / Paul Kiptoo, Anna M. Calcagno, and Teruna J. Siahaan ; 2.1. Introduction ; 2.2. Physiological Barriers to Drug Delivery ; 2.2.1. Paracellular Pathway ; 2.2.2. Transcellular Pathway ; 2.3. Biochemical Barriers to Drug Delivery ; 2.3.1. Metabolizing Enzymes ; 2.3.2. Transporters and Efflux Pumps ; 2.4. Chemical Barriers to Drug Delivery ; 2.4.1. Hydrogen-Bonding Potential ; 2.4.2. Other Properties ; 2.5. Drug Modifications to Enhance Transport Across Biological Barriers ; 2.5.1. Prodrugs and Structural Modifications ; 2.5.2. Formulations ; 2.6. Conclusions ; References ; 3 Physicochemical Properties, Formulation, and Drug Delivery / Dewey H. Barich, Mark T. Zell, and Eric J. Munson ; 3.1. Introduction ; 3.2. Physicochemical Properties ; 3.2.1. Solubility ; 3.2.2. Stability ; 3.3. Formulations ; 3.3.1. Processing steps ; 3.3.2. Influence of physicochemical properties on drugs in formulations ; 3.3.3. Other issues ; 3.4. Drug Delivery ; 3.4.1. Duration of Release ; 3.4.2. Site of Administration ; 3.4.3. Methods of Administration ; 3.5. Conclusion ; References ; 4 Targeted Bioavailability: A Fresh Look at Pharmacokinetics and Pharmacodynamics Issues in Drug Discovery and Development / Christine Xu ; 4.1. Introduction ; 4.2. Target bioavailability ; 4.3. Drug delivery trends and targets related to pharmacokinetics and pharmacodynamics ; 4.4. Pharmacokinetics (PK) -- pharmacodynamics (PD) in drug discovery and development ; 4.5. Source of variability of drug response ; 4.6. Recent development and issues of bio-analytical methodology ; 4.7. Mechanistic PK-PD models ; 4.8. Summary ; References ; 5 The Role of Transporters in Drug Delivery and Excretion / Marilyn E. Morris and Xiaowen Guan ; 5.1. Introduction ; 5.2. Drug Transport in absorption and excretion. ; 5.2.1. Intestinal transport ; 5.2.2. Hepatic Transport ; 5.2.3. Renal Transport ; 5.2.4. Blood-brain barrier transport ; 5.3. ABC (ATP-binding cassette) transporter family ; 5.3.1. P-glycoprotein (ABCB1) ; 5.3.2. Multidrug Resistance-associated Proteins (ABCC) ; 5.3.3. Breast Cancer Resistance Protein (ABCG2) ; 5.3.4. Other ABC transporters ; 5.4. SLC (solute carrier) transporter family ; 5.4.1. Organic Anion Transporting Polypeptides (SLCO) ; 5.4.2. Organic Anion Transporters (SLC22A) ; 5.4.3. Organic Cation Transporters (SLC22) ; 5.4.4. Multidrug and Toxin Extrusion Transporters (SLC47A) ; 5.4.5. Monocarboxylate Transporters (SLC16 and SLC5) ; 5.4.6. Peptide Transporters (SLC15A) ; 5.4.7. Other SLC transporters ; 5.5. Conclusions ; References ; 6 Intracellular delivery and disposition of small molecular weight drugs / Jeffrey Krise ; 6.1 Introduction ; 6.2. The relationship between the intracellular distribution of a drug and its activity ; 6.3
Control code
926623506
Edition
Second edition.
Extent
1 online resource
Form of item
online
Isbn
9781118833322
Lccn
2015041751
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
http://library.link/vocab/ext/overdrive/overdriveId
9781118833308
Specific material designation
remote
System control number
(OCoLC)926623506

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