Coverart for item
The Resource Endocrine disruption and human health, edited by Philippa D. Darbre, BScHons, PhD

Endocrine disruption and human health, edited by Philippa D. Darbre, BScHons, PhD

Label
Endocrine disruption and human health
Title
Endocrine disruption and human health
Statement of responsibility
edited by Philippa D. Darbre, BScHons, PhD
Contributor
Editor
Subject
Genre
Language
eng
Summary
Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human healthPresents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human healthOffers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Cataloging source
N$T
Dewey number
615.3/6
Illustrations
illustrations
Index
index present
LC call number
RA1224.2
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Darbre, Philippa D.
http://library.link/vocab/subjectName
  • Endocrine disrupting chemicals
  • Endocrine Disruptors
  • MEDICAL
Label
Endocrine disruption and human health, edited by Philippa D. Darbre, BScHons, PhD
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Front Cover; Endocrine Disruption and Human Health; Copyright Page; Contents; List of Contributors; Preface; 1 Overview and Scope; 1 What Are Endocrine Disrupters and Where Are They Found?; 1.1 Introduction; 1.2 Historical Background; 1.3 Evidence for Endocrine Disruption in Wildlife Populations and How This May Predict Effects on Human Health; 1.3.1 TBT and Imposex in Mollusks; 1.3.2 Dicofol and Reproduction of Alligators; 1.3.3 Feminization of Male Fish in the UK Rivers; 1.3.4 Eggshell Thinning in Birds; 1.4 Which Hormones Are Disrupted by EDCs?; 1.5 How Do EDCs Disrupt Hormone Action?
  • 1.6 Which Chemicals Are Sources of Human Exposure to Endocrine Disrupters?1.6.1 Persistent Organic Pollutants-"The Dirty Dozen"; 1.6.2 POPs-Others; 1.6.3 The Herbicides Atrazine and Glyphosate; 1.6.4 Bisphenol A; 1.6.5 Phthalates; 1.6.6 Alkylphenols; 1.6.7 Triclosan; 1.6.8 Parabens; 1.6.9 UV Filters; 1.6.10 Organometals and Metals; 1.6.11 Other EDCs in Personal Care Products; 1.6.12 Synthetic Hormones; 1.6.13 Paracetamol; 1.6.14 Mycoestrogens; 1.6.15 Phytoestrogens; 1.6.16 Nutraceuticals; References; 2 How Could Endocrine Disrupters Affect Human Health?; 2.1 Introduction
  • 2.2 Entry into Human Tissues2.3 Can EDCs Be Absorbed from Dermal Application?; 2.4 Tissue Measurements; 2.4.1 Biomarkers; 2.5 Role of Metabolism in Biological Activity of EDCs; 2.5.1 Metabolism May Alter the Endocrine-Disrupting Properties of an EDC; 2.5.2 EDCs May Alter Endogenous Enzyme Activities; 2.6 Biological Availability; 2.6.1 Binding to Serum Proteins; 2.6.2 Modification by Conjugation; 2.7 Dose-Response Considerations; 2.7.1 Receptor Binding Affinity Versus Response Efficacy; 2.7.2 Effect of Length of Time on Response; 2.8 Effect of Exposure to Mixtures of Chemicals
  • 2.9 Effect of Timing of Exposure2.9.1 Critical Windows of Susceptibility; 2.9.2 Latency Periods; 2.10 Transgenerational Effects; 2.11 EDCs Do Not Have the Same Effect in All Tissues; 2.12 EDCs Do Not Have the Same Effects in Every Individual: The Interaction of Genetics with Environment; References; 2 Mechanisms and Assay Systems; 3 Disrupters of Estrogen Action and Synthesis; 3.1 Physiological Actions of Estrogen and Implications of Disruption; 3.2 Molecular Actions of Estrogen and Mechanisms of Disruption; 3.2.1 Direct Genomic Action; 3.2.2 Indirect Genomic Action; 3.2.3 Nongenomic Action
  • 3.3 Synthesis of Endogenous Estrogens and Disruption of Necessary Enzymatic Activities3.4 Assay Systems; 3.4.1 Can a Compound Bind to ER?-ER-Binding Assays in a Cell-Free System; 3.4.2 Can Binding of a Compound to ER Regulate Estrogen-Responsive Gene Expression in Cells In Vitro?; 3.4.2.1 Reporter Gene Assays; 3.4.2.2 Endogenous Gene Assays; 3.4.3 Can Binding of the Compound to ER Increase Proliferation of Estrogen-Responsive Cells In Vitro?; 3.4.4 Can the Compound Increase Uterine Weight in the Immature Rodent In Vivo?; 3.4.5 Can the Compound Interfere with Biosynthesis of Estrogens?
Control code
905543996
Dimensions
unknown
Extent
1 online resource (xii, 377 pages)
File format
unknown
Form of item
online
Isbn
9780128011201
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color)
http://library.link/vocab/ext/overdrive/overdriveId
9780128011201
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)905543996
Label
Endocrine disruption and human health, edited by Philippa D. Darbre, BScHons, PhD
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Front Cover; Endocrine Disruption and Human Health; Copyright Page; Contents; List of Contributors; Preface; 1 Overview and Scope; 1 What Are Endocrine Disrupters and Where Are They Found?; 1.1 Introduction; 1.2 Historical Background; 1.3 Evidence for Endocrine Disruption in Wildlife Populations and How This May Predict Effects on Human Health; 1.3.1 TBT and Imposex in Mollusks; 1.3.2 Dicofol and Reproduction of Alligators; 1.3.3 Feminization of Male Fish in the UK Rivers; 1.3.4 Eggshell Thinning in Birds; 1.4 Which Hormones Are Disrupted by EDCs?; 1.5 How Do EDCs Disrupt Hormone Action?
  • 1.6 Which Chemicals Are Sources of Human Exposure to Endocrine Disrupters?1.6.1 Persistent Organic Pollutants-"The Dirty Dozen"; 1.6.2 POPs-Others; 1.6.3 The Herbicides Atrazine and Glyphosate; 1.6.4 Bisphenol A; 1.6.5 Phthalates; 1.6.6 Alkylphenols; 1.6.7 Triclosan; 1.6.8 Parabens; 1.6.9 UV Filters; 1.6.10 Organometals and Metals; 1.6.11 Other EDCs in Personal Care Products; 1.6.12 Synthetic Hormones; 1.6.13 Paracetamol; 1.6.14 Mycoestrogens; 1.6.15 Phytoestrogens; 1.6.16 Nutraceuticals; References; 2 How Could Endocrine Disrupters Affect Human Health?; 2.1 Introduction
  • 2.2 Entry into Human Tissues2.3 Can EDCs Be Absorbed from Dermal Application?; 2.4 Tissue Measurements; 2.4.1 Biomarkers; 2.5 Role of Metabolism in Biological Activity of EDCs; 2.5.1 Metabolism May Alter the Endocrine-Disrupting Properties of an EDC; 2.5.2 EDCs May Alter Endogenous Enzyme Activities; 2.6 Biological Availability; 2.6.1 Binding to Serum Proteins; 2.6.2 Modification by Conjugation; 2.7 Dose-Response Considerations; 2.7.1 Receptor Binding Affinity Versus Response Efficacy; 2.7.2 Effect of Length of Time on Response; 2.8 Effect of Exposure to Mixtures of Chemicals
  • 2.9 Effect of Timing of Exposure2.9.1 Critical Windows of Susceptibility; 2.9.2 Latency Periods; 2.10 Transgenerational Effects; 2.11 EDCs Do Not Have the Same Effect in All Tissues; 2.12 EDCs Do Not Have the Same Effects in Every Individual: The Interaction of Genetics with Environment; References; 2 Mechanisms and Assay Systems; 3 Disrupters of Estrogen Action and Synthesis; 3.1 Physiological Actions of Estrogen and Implications of Disruption; 3.2 Molecular Actions of Estrogen and Mechanisms of Disruption; 3.2.1 Direct Genomic Action; 3.2.2 Indirect Genomic Action; 3.2.3 Nongenomic Action
  • 3.3 Synthesis of Endogenous Estrogens and Disruption of Necessary Enzymatic Activities3.4 Assay Systems; 3.4.1 Can a Compound Bind to ER?-ER-Binding Assays in a Cell-Free System; 3.4.2 Can Binding of a Compound to ER Regulate Estrogen-Responsive Gene Expression in Cells In Vitro?; 3.4.2.1 Reporter Gene Assays; 3.4.2.2 Endogenous Gene Assays; 3.4.3 Can Binding of the Compound to ER Increase Proliferation of Estrogen-Responsive Cells In Vitro?; 3.4.4 Can the Compound Increase Uterine Weight in the Immature Rodent In Vivo?; 3.4.5 Can the Compound Interfere with Biosynthesis of Estrogens?
Control code
905543996
Dimensions
unknown
Extent
1 online resource (xii, 377 pages)
File format
unknown
Form of item
online
Isbn
9780128011201
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations (some color)
http://library.link/vocab/ext/overdrive/overdriveId
9780128011201
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)905543996

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      37.955220 -91.772210
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