The Resource Guideline-directed statin therapy in patients with new or worsening symptoms of peripheral artery disease, by Yevgeniy Khariton

Guideline-directed statin therapy in patients with new or worsening symptoms of peripheral artery disease, by Yevgeniy Khariton

Label
Guideline-directed statin therapy in patients with new or worsening symptoms of peripheral artery disease
Title
Guideline-directed statin therapy in patients with new or worsening symptoms of peripheral artery disease
Statement of responsibility
by Yevgeniy Khariton
Creator
Contributor
Author
Degree supervisor
Subject
Genre
Language
eng
Summary
Objective: The ACC/AHA cholesterol guidelines recommend patients with peripheral artery disease (PAD) be treated with a moderate to high-intensity statin. The extent to which PAD patients with new or worsening claudication symptoms are offered guideline statin therapy is unknown. Methods: In the PORTRAIT registry, patterns of statin therapy were assessed in 1144 patients at 16 PAD specialty clinics (between June 2011-December 2015) before and after an evaluation for new or worsening claudication symptoms. It was documented whether patients had been previously treated with a guideline-directed statin as well as switched from non guideline to guideline statin therapy. Patient factors predicting intensification to guideline statin were examined. Site and provider-level variation in guideline statin intensification were summarized by calculating median odds ratios. Results: Among 1144 patients, 810 (70.8%) were initially on guideline therapy compared with 334 (29.2%) that were not. In the latter, 103 (30.8%) were prescribed guideline therapy after evaluation. Patients with typical symptoms displayed greater odds of intensification to guideline statin (OR 3.75; 95% CI: 1.22-11.53) while older patients had lower odds (OR 0.60/decade; 95% CI: 0.40-0.87). Variability in guideline statin intensification was observed across sites (Adjusted Median Odds Ratio = 3.63; 95% CI 1.88-5.42, (p <0.05)) but not providers (Adjusted Median Odds Ratio = 1.90; 95% CI 1.00-2.55, (p >0.05)). Conclusions: In conclusion, most patients evaluated at a PAD specialty clinic for new or worsening claudication symptoms arrived on a guideline-directed statin. Only 31% originally off guideline therapy were intensified to a guideline statin. These findings highlight an important opportunity to optimize medical therapy for patients with PAD
Cataloging source
UMK
http://library.link/vocab/creatorDate
1989-
http://library.link/vocab/creatorName
Khariton, Yevgeniy
Degree
M.S.
Dissertation note
(School of Medicine).
Dissertation year
2018.
Granting institution
University of Missouri-Kansas City,
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Smolderen, Kim G.
http://library.link/vocab/subjectName
  • Statins (Cardiovascular agents)
  • Peripheral vascular diseases
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Peripheral Arterial Disease
Label
Guideline-directed statin therapy in patients with new or worsening symptoms of peripheral artery disease, by Yevgeniy Khariton
Instantiates
Publication
Copyright
Note
  • "A thesis in Bioinformatics."
  • Advisor: Kim Smolderen
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 39-46)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Methods -- Results -- Discussion -- Tables and figures -- SAS syntax
Control code
1104539356
Dimensions
unknown
Extent
1 online resource (47 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)1104539356
System details
  • The full text of the thesis is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web
Label
Guideline-directed statin therapy in patients with new or worsening symptoms of peripheral artery disease, by Yevgeniy Khariton
Publication
Copyright
Note
  • "A thesis in Bioinformatics."
  • Advisor: Kim Smolderen
  • Vita
Antecedent source
not applicable
Bibliography note
Includes bibliographical references (pages 39-46)
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Introduction -- Methods -- Results -- Discussion -- Tables and figures -- SAS syntax
Control code
1104539356
Dimensions
unknown
Extent
1 online resource (47 pages)
File format
one file format
Form of item
online
Level of compression
mixed
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations.
Quality assurance targets
not applicable
Specific material designation
remote
System control number
(OCoLC)1104539356
System details
  • The full text of the thesis is available as an Adobe Acrobat .pdf file; Adobe Acrobat Reader required to view the file
  • Mode of access: World Wide Web

Library Locations

  • Curtis Laws Wilson LibraryBorrow it
    400 West 14th Street, Rolla, MO, 65409, US
    37.955220 -91.772210
  • Missouri University of Science & Technology Library DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
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