The Resource Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)

Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)

Label
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
Title
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
Statement of responsibility
by Arvind Shakya
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
Atherosclerosis is characterized by the narrowing of the arterial lumen due to formation of the plaque within the intimal layer of the arterial wall resulting in the impaired flow of blood to the target organs. Most severe consequences of atherosclerosis arise due to the rupture of the atherosclerotic plaque, which is the cause of stroke, myocardial infarction, etc. Rupture of the plaque occurs due to the thinning of the fibrous cap of the plaque. Increased expression of matrix metalloproteinases (MMPs), including MMP-14, the enzymes which can cause degradation of many components of the extracellular matrix, is the cause of thinning and rupture of the fibrous cap of the atherosclerotic plaque. Increased expression of MMP-14 is due to its transcriptional upregulation during inflammatory conditions such as atherosclerosis. In a recent study, we have shown that serum amyloid A-activating factor-1 (SAF-1) is involved in the increased expression of MMP-14 in the atherosclerotic lesion area. This discovery is a major breakthrough in understanding the regulation of MMP-14 gene expression during inflammatory conditions. However, we still do not have a clear understanding of the regulatory processes that are involved in the expression of MMP-14 during physiological and pathological conditions. We here show that another transcription factor, octamer binding protein-1 (Oct-1) may be involved in the regulation of MMP-14. We have here shown that there is physical interaction between SAF-1 and Oct-1, and Oct-1 may be involved in controlling SAF-1 mediated expression ofMMP-14 gene. The crucial finding that Oct-1 is a downreguator of MMP-14 gene may be an important target for developing new therapeutic measures for the treatment of atherosclerosis
Cataloging source
MMU
http://library.link/vocab/creatorName
Shakya, Arvind
Degree
Ph. D.
Dissertation year
2006.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
Ray, Bimal K., 1951-
http://library.link/vocab/subjectName
  • Atherosclerosis
  • Atherosclerotic plague
  • Metalloproteinases
  • Transcription factors
Target audience
specialized
Label
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)
Instantiates
Publication
Note
  • "December 2006"
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
164587966
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)164587966
System details
Mode of access: World Wide Web
Label
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)
Publication
Note
  • "December 2006"
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Vita
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
164587966
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)164587966
System details
Mode of access: World Wide Web

Library Locations

  • Curtis Laws Wilson LibraryBorrow it
    400 West 14th Street, Rolla, MO, 65409, US
    37.955220 -91.772210
  • Missouri University of Science & Technology Library DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
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