The Resource Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)
Resource Information
The item Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.This item is available to borrow from all library branches.
Resource Information
The item Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.
This item is available to borrow from all library branches.
- Summary
- Atherosclerosis is characterized by the narrowing of the arterial lumen due to formation of the plaque within the intimal layer of the arterial wall resulting in the impaired flow of blood to the target organs. Most severe consequences of atherosclerosis arise due to the rupture of the atherosclerotic plaque, which is the cause of stroke, myocardial infarction, etc. Rupture of the plaque occurs due to the thinning of the fibrous cap of the plaque. Increased expression of matrix metalloproteinases (MMPs), including MMP-14, the enzymes which can cause degradation of many components of the extracellular matrix, is the cause of thinning and rupture of the fibrous cap of the atherosclerotic plaque. Increased expression of MMP-14 is due to its transcriptional upregulation during inflammatory conditions such as atherosclerosis. In a recent study, we have shown that serum amyloid A-activating factor-1 (SAF-1) is involved in the increased expression of MMP-14 in the atherosclerotic lesion area. This discovery is a major breakthrough in understanding the regulation of MMP-14 gene expression during inflammatory conditions. However, we still do not have a clear understanding of the regulatory processes that are involved in the expression of MMP-14 during physiological and pathological conditions. We here show that another transcription factor, octamer binding protein-1 (Oct-1) may be involved in the regulation of MMP-14. We have here shown that there is physical interaction between SAF-1 and Oct-1, and Oct-1 may be involved in controlling SAF-1 mediated expression ofMMP-14 gene. The crucial finding that Oct-1 is a downreguator of MMP-14 gene may be an important target for developing new therapeutic measures for the treatment of atherosclerosis
- Language
- eng
- Note
-
- "December 2006"
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Vita
- Label
- Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
- Title
- Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
- Statement of responsibility
- by Arvind Shakya
- Language
- eng
- Summary
- Atherosclerosis is characterized by the narrowing of the arterial lumen due to formation of the plaque within the intimal layer of the arterial wall resulting in the impaired flow of blood to the target organs. Most severe consequences of atherosclerosis arise due to the rupture of the atherosclerotic plaque, which is the cause of stroke, myocardial infarction, etc. Rupture of the plaque occurs due to the thinning of the fibrous cap of the plaque. Increased expression of matrix metalloproteinases (MMPs), including MMP-14, the enzymes which can cause degradation of many components of the extracellular matrix, is the cause of thinning and rupture of the fibrous cap of the atherosclerotic plaque. Increased expression of MMP-14 is due to its transcriptional upregulation during inflammatory conditions such as atherosclerosis. In a recent study, we have shown that serum amyloid A-activating factor-1 (SAF-1) is involved in the increased expression of MMP-14 in the atherosclerotic lesion area. This discovery is a major breakthrough in understanding the regulation of MMP-14 gene expression during inflammatory conditions. However, we still do not have a clear understanding of the regulatory processes that are involved in the expression of MMP-14 during physiological and pathological conditions. We here show that another transcription factor, octamer binding protein-1 (Oct-1) may be involved in the regulation of MMP-14. We have here shown that there is physical interaction between SAF-1 and Oct-1, and Oct-1 may be involved in controlling SAF-1 mediated expression ofMMP-14 gene. The crucial finding that Oct-1 is a downreguator of MMP-14 gene may be an important target for developing new therapeutic measures for the treatment of atherosclerosis
- Cataloging source
- MMU
- http://library.link/vocab/creatorName
- Shakya, Arvind
- Degree
- Ph. D.
- Dissertation year
- 2006.
- Granting institution
- University of Missouri-Columbia
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- theses
- http://library.link/vocab/relatedWorkOrContributorName
- Ray, Bimal K., 1951-
- http://library.link/vocab/subjectName
-
- Atherosclerosis
- Atherosclerotic plague
- Metalloproteinases
- Transcription factors
- Target audience
- specialized
- Label
- Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)
- Note
-
- "December 2006"
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Vita
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 164587966
- Dimensions
- unknown
- Form of item
- electronic
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)164587966
- System details
- Mode of access: World Wide Web
- Label
- Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)
- Note
-
- "December 2006"
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Vita
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 164587966
- Dimensions
- unknown
- Form of item
- electronic
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)164587966
- System details
- Mode of access: World Wide Web
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.mst.edu/portal/Mechanism-of-matrix-metalloproteinase-14-mmp-14/Cp8qQ5FpgEo/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.mst.edu/portal/Mechanism-of-matrix-metalloproteinase-14-mmp-14/Cp8qQ5FpgEo/">Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis, by Arvind Shakya, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.mst.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.mst.edu/">Missouri University of Science & Technology Library</a></span></span></span></span></div>
