The Resource Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler
Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler
Resource Information
The item Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.This item is available to borrow from 1 library branch.
Resource Information
The item Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.
This item is available to borrow from 1 library branch.
- Summary
- The human pathogens Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. In contrast, there are no current vaccination prospects for N. gonorrhoeae, the causative agent of sexually transmitted gonorrhoea. Historically, infections caused by N. gonorrhoeae were treated with antibiotics. However, the
- Language
- eng
- Extent
- 1 online resource
- Contents
-
- Contributors; Preface; 1: Genomics and Reference Libraries; Introduction; Bacterial typing using nucleotide sequencing; Clonal complexes; Sequence typing databases; Antigen typing; Antibiotic resistance genes; Data management; The Bacterial Isolate Genome Sequence Database (BIGSdb) platform; Genome Comparator and whole genome MLST; Neisseria genomes on PubMLST.org; Community-based annotation; Automated extraction of clinically relevant information; Neisseria speciation using standard and ribosomal MLST; Discussion; Future trends
- 2: Transcriptional Regulatory Proteins in the Pathogenic NeisseriaIntroduction; Clinical and biological relevance of Neisseria transcriptional regulators in general and Fur in particular; Mechanism of regulation of the ferric uptake regulator (Fur); Fur acts as a global regulator in the pathogenic Neisseria; Direct Fur regulation; Indirect Fur regulation; Fur cross-talk with other regulatory circuits; Conclusions; Future trends; 3: The Regulatory Small RNAs of Neisseria; Introduction; Identification of sRNAs of N. meningitidis and N. gonorrhoeae; Functional analysis of sRNAs in Neisseria
- ConclusionsFuture trends; Inter- and Intraspecies Transformation in the Neisseria: Mechanism, Evolution and DNA Uptake Sequenc; Introduction; Inter- and intraspecies transformation in the neisseriae; Restriction modification and transformation; Transformation mechanism; DNA uptake sequence specificity of the Neisseria; Discussion and conclusions; Future trends; 5: Pathogenic Neisseria: Neither Aerobes nor True Anaerobes, but Dedicated Microaerophiles; Introduction; Aerobic growth of neisserial species; Why might Neisseria not be able to grow anaerobically?
- Effect of oxygen limitation on serum resistance and pathogenicityFNR in the gonococcus; Gonococcal survival during oxygen starvation; Reduction of nitric oxide, the toxic product of nitrite reduction; Neisserial denitrification and pathogenicity; Other physiological roles of the neisserial FNR transcription activators; Evidence that the meningococcal FNR is less oxygen sensitive than the gonococcal FNR; Outer membrane lipoproteins as the first line of defence against chemical attack by the host; Electron transfer to outer membrane lipoproteins; Overview of nitrosative damage
- Repair of nitrosative damageConclusions: niche adaptation and pathogenicity; Future trends; 6: Peptidoglycan Metabolism and Fragment Production; Introduction; Overview of Neisseria cell wall structure; Cell wall growth, septation and separation; Autolysis; Release of PG fragments by N. gonorrhoeae; Enzymes involved in peptidoglycan liberation from the cell wall; Peptidoglycan acetylation; Recycling of peptidoglycan fragments; Starvation response in the absence of peptidoglycan recycling; Meningococcal PG fragment release; Responses to released PG fragments
- Isbn
- 9781908230614
- Label
- Pathogenic Neisseria : genomics, molecular biology and disease intervention
- Title
- Pathogenic Neisseria
- Title remainder
- genomics, molecular biology and disease intervention
- Statement of responsibility
- edited by John K. Davies and Charlene M. Kahler
- Language
- eng
- Summary
- The human pathogens Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. In contrast, there are no current vaccination prospects for N. gonorrhoeae, the causative agent of sexually transmitted gonorrhoea. Historically, infections caused by N. gonorrhoeae were treated with antibiotics. However, the
- Cataloging source
- N$T
- Dewey number
- 614.57
- Index
- no index present
- LC call number
- QR201.N45
- Literary form
- non fiction
- Nature of contents
- dictionaries
- NLM call number
-
- 2014 L-481
- QW 131
- http://library.link/vocab/relatedWorkOrContributorName
-
- Davies, John K.
- Kahler, Charlene M.
- http://library.link/vocab/subjectName
-
- Neisseria infections
- Neisseria gonorrhoeae
- Neisseria gonorrhoeae
- Neisseria meningitidis
- MEDICAL
- MEDICAL
- MEDICAL
- Neisseria gonorrhoeae
- Neisseria infections
- Label
- Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler
- Antecedent source
- unknown
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Contributors; Preface; 1: Genomics and Reference Libraries; Introduction; Bacterial typing using nucleotide sequencing; Clonal complexes; Sequence typing databases; Antigen typing; Antibiotic resistance genes; Data management; The Bacterial Isolate Genome Sequence Database (BIGSdb) platform; Genome Comparator and whole genome MLST; Neisseria genomes on PubMLST.org; Community-based annotation; Automated extraction of clinically relevant information; Neisseria speciation using standard and ribosomal MLST; Discussion; Future trends
- 2: Transcriptional Regulatory Proteins in the Pathogenic NeisseriaIntroduction; Clinical and biological relevance of Neisseria transcriptional regulators in general and Fur in particular; Mechanism of regulation of the ferric uptake regulator (Fur); Fur acts as a global regulator in the pathogenic Neisseria; Direct Fur regulation; Indirect Fur regulation; Fur cross-talk with other regulatory circuits; Conclusions; Future trends; 3: The Regulatory Small RNAs of Neisseria; Introduction; Identification of sRNAs of N. meningitidis and N. gonorrhoeae; Functional analysis of sRNAs in Neisseria
- ConclusionsFuture trends; Inter- and Intraspecies Transformation in the Neisseria: Mechanism, Evolution and DNA Uptake Sequenc; Introduction; Inter- and intraspecies transformation in the neisseriae; Restriction modification and transformation; Transformation mechanism; DNA uptake sequence specificity of the Neisseria; Discussion and conclusions; Future trends; 5: Pathogenic Neisseria: Neither Aerobes nor True Anaerobes, but Dedicated Microaerophiles; Introduction; Aerobic growth of neisserial species; Why might Neisseria not be able to grow anaerobically?
- Effect of oxygen limitation on serum resistance and pathogenicityFNR in the gonococcus; Gonococcal survival during oxygen starvation; Reduction of nitric oxide, the toxic product of nitrite reduction; Neisserial denitrification and pathogenicity; Other physiological roles of the neisserial FNR transcription activators; Evidence that the meningococcal FNR is less oxygen sensitive than the gonococcal FNR; Outer membrane lipoproteins as the first line of defence against chemical attack by the host; Electron transfer to outer membrane lipoproteins; Overview of nitrosative damage
- Repair of nitrosative damageConclusions: niche adaptation and pathogenicity; Future trends; 6: Peptidoglycan Metabolism and Fragment Production; Introduction; Overview of Neisseria cell wall structure; Cell wall growth, septation and separation; Autolysis; Release of PG fragments by N. gonorrhoeae; Enzymes involved in peptidoglycan liberation from the cell wall; Peptidoglycan acetylation; Recycling of peptidoglycan fragments; Starvation response in the absence of peptidoglycan recycling; Meningococcal PG fragment release; Responses to released PG fragments
- Control code
- 883900051
- Dimensions
- unknown
- Extent
- 1 online resource
- File format
- unknown
- Form of item
- online
- Isbn
- 9781908230614
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)883900051
- Label
- Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler
- Antecedent source
- unknown
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Contributors; Preface; 1: Genomics and Reference Libraries; Introduction; Bacterial typing using nucleotide sequencing; Clonal complexes; Sequence typing databases; Antigen typing; Antibiotic resistance genes; Data management; The Bacterial Isolate Genome Sequence Database (BIGSdb) platform; Genome Comparator and whole genome MLST; Neisseria genomes on PubMLST.org; Community-based annotation; Automated extraction of clinically relevant information; Neisseria speciation using standard and ribosomal MLST; Discussion; Future trends
- 2: Transcriptional Regulatory Proteins in the Pathogenic NeisseriaIntroduction; Clinical and biological relevance of Neisseria transcriptional regulators in general and Fur in particular; Mechanism of regulation of the ferric uptake regulator (Fur); Fur acts as a global regulator in the pathogenic Neisseria; Direct Fur regulation; Indirect Fur regulation; Fur cross-talk with other regulatory circuits; Conclusions; Future trends; 3: The Regulatory Small RNAs of Neisseria; Introduction; Identification of sRNAs of N. meningitidis and N. gonorrhoeae; Functional analysis of sRNAs in Neisseria
- ConclusionsFuture trends; Inter- and Intraspecies Transformation in the Neisseria: Mechanism, Evolution and DNA Uptake Sequenc; Introduction; Inter- and intraspecies transformation in the neisseriae; Restriction modification and transformation; Transformation mechanism; DNA uptake sequence specificity of the Neisseria; Discussion and conclusions; Future trends; 5: Pathogenic Neisseria: Neither Aerobes nor True Anaerobes, but Dedicated Microaerophiles; Introduction; Aerobic growth of neisserial species; Why might Neisseria not be able to grow anaerobically?
- Effect of oxygen limitation on serum resistance and pathogenicityFNR in the gonococcus; Gonococcal survival during oxygen starvation; Reduction of nitric oxide, the toxic product of nitrite reduction; Neisserial denitrification and pathogenicity; Other physiological roles of the neisserial FNR transcription activators; Evidence that the meningococcal FNR is less oxygen sensitive than the gonococcal FNR; Outer membrane lipoproteins as the first line of defence against chemical attack by the host; Electron transfer to outer membrane lipoproteins; Overview of nitrosative damage
- Repair of nitrosative damageConclusions: niche adaptation and pathogenicity; Future trends; 6: Peptidoglycan Metabolism and Fragment Production; Introduction; Overview of Neisseria cell wall structure; Cell wall growth, septation and separation; Autolysis; Release of PG fragments by N. gonorrhoeae; Enzymes involved in peptidoglycan liberation from the cell wall; Peptidoglycan acetylation; Recycling of peptidoglycan fragments; Starvation response in the absence of peptidoglycan recycling; Meningococcal PG fragment release; Responses to released PG fragments
- Control code
- 883900051
- Dimensions
- unknown
- Extent
- 1 online resource
- File format
- unknown
- Form of item
- online
- Isbn
- 9781908230614
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)883900051
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.mst.edu/portal/Pathogenic-Neisseria--genomics-molecular/UB54mC9pBmc/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.mst.edu/portal/Pathogenic-Neisseria--genomics-molecular/UB54mC9pBmc/">Pathogenic Neisseria : genomics, molecular biology and disease intervention, edited by John K. Davies and Charlene M. Kahler</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.mst.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.mst.edu/">Missouri University of Science & Technology Library</a></span></span></span></span></div>
