Coverart for item
The Resource Polymers and nanomaterials for gene therapy, edited by Ravin Narain

Polymers and nanomaterials for gene therapy, edited by Ravin Narain

Label
Polymers and nanomaterials for gene therapy
Title
Polymers and nanomaterials for gene therapy
Statement of responsibility
edited by Ravin Narain
Contributor
Editor
Subject
Genre
Language
eng
Summary
Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy
Member of
Cataloging source
N$T
Dewey number
610.28
Index
index present
LC call number
R857.P6
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
Narain, Ravin
Series statement
Woodhead publishing series in biomedicine
Series volume
numbers 83
http://library.link/vocab/subjectName
  • Polymers in medicine
  • Nanomedicine
  • Gene therapy
  • HEALTH & FITNESS / Holism
  • HEALTH & FITNESS / Reference
  • MEDICAL / Alternative Medicine
  • MEDICAL / Atlases
  • MEDICAL / Essays
  • MEDICAL / Family & General Practice
  • MEDICAL / Holistic Medicine
  • MEDICAL / Osteopathy
  • Gene therapy
  • Nanomedicine
  • Polymers in medicine
Label
Polymers and nanomaterials for gene therapy, edited by Ravin Narain
Instantiates
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • PrefaceChapter 1: Mechanism, current challenges and new approaches for non viral gene delivery; 1.1 Introduction; 1.2 Current non-viral gene delivery vectors; 1.2.1 Naked DNA; 1.2.2 Cationic lipids; 1.2.2.1 Liposomes; 1.2.2.2 Lipid-coated DNA complexes; 1.2.2.3 Niosomes; 1.2.3 Cationic polymers; 1.2.3.1 Polyethylenimine (PEI); 1.2.3.2 Poly-L-lysine (PLL); 1.2.3.3 Polymethacrylate; 1.2.3.4 Chitosan; 1.2.3.5 Dendrimers; 1.2.3.5.1 Polyamidoamine dendrimers (PAMAM); 1.2.3.5.2 Poly(propylenimine) dendrimers (PPI); 1.2.3.5.3 Poly(L-lysine) dendrimers
  • 1.3 Trajectory and mechanism of non-viral vectors1.3.1 Basics of non-viral gene delivery system formulation; 1.3.1.1 Complexes between cationic lipid and DNA (lipoplexes); 1.3.1.2 Complexes between cationic polymer and DNA (polyplexes); 1.3.2 Binding and uptake; 1.3.2.1 Phagocytosis; 1.3.2.2 Clathrin-mediated endocytosis; 1.3.2.3 Caveolae-mediated endocytosis; 1.3.2.4 Macropinocytosis; 1.3.2.5 Non-endocytic pathways; 1.3.3 Characteristics of non-viral gene delivery influencing uptake pathways; 1.3.3.1 Size; 1.3.3.2 Surface charge; 1.3.3.3 Shape; 1.3.3.4 Cell type
  • 1.3.4 Endosomal escape and dissociation of complexes1.3.4.1 Lipoplexes; 1.3.4.2 Polyplexes; 1.3.5 Fate in cytoplasm and nuclear entry; 1.4 Conclusion and future perspective; References; Chapter 2: PEI and its derivatives for gene therapy; 2.1 Introduction; 2.2 Criteria for non-viral vectors and general considerations; 2.3 Rationale for the use of PEI for gene therapy; 2.4 PEI Derivatives for gene delivery; 2.4.1 Grafting targeting ligands on PEI; 2.4.2 Chemical modification to shield cationic charge density; 2.4.3 Hydrophobic modifications; 2.4.4 Stimuli-sensitive construct
  • 2.4.4.1 Redox-sensitive construct2.4.5 pH-sensitive PEI constructs; 2.4.6 Temperature-sensitive PEI constructs; 2.5 PEGylation of PEI; 2.6 Polyester conjugation on PEI; 2.7 Chitosan conjugation on PEI; 2.8 PLL conjugation on PEI; 2.9 Metallic nanoparticles with PEIs; 2.10 Pharmacokinetics and bio-distribution of PEI delivery vectors; 2.11 Concluding remarks; Acknowledgements; References; Chapter 3: Natural polymers in nucleic acid delivery; 3.1 Introducing cells to exogenous nucleic acids; 3.1.1 Nucleic acids as therapeutics; 3.1.2 Applications in cancer
Control code
934626627
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9780081005217
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
http://library.link/vocab/ext/overdrive/overdriveId
887354
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)934626627
Label
Polymers and nanomaterials for gene therapy, edited by Ravin Narain
Publication
Copyright
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • PrefaceChapter 1: Mechanism, current challenges and new approaches for non viral gene delivery; 1.1 Introduction; 1.2 Current non-viral gene delivery vectors; 1.2.1 Naked DNA; 1.2.2 Cationic lipids; 1.2.2.1 Liposomes; 1.2.2.2 Lipid-coated DNA complexes; 1.2.2.3 Niosomes; 1.2.3 Cationic polymers; 1.2.3.1 Polyethylenimine (PEI); 1.2.3.2 Poly-L-lysine (PLL); 1.2.3.3 Polymethacrylate; 1.2.3.4 Chitosan; 1.2.3.5 Dendrimers; 1.2.3.5.1 Polyamidoamine dendrimers (PAMAM); 1.2.3.5.2 Poly(propylenimine) dendrimers (PPI); 1.2.3.5.3 Poly(L-lysine) dendrimers
  • 1.3 Trajectory and mechanism of non-viral vectors1.3.1 Basics of non-viral gene delivery system formulation; 1.3.1.1 Complexes between cationic lipid and DNA (lipoplexes); 1.3.1.2 Complexes between cationic polymer and DNA (polyplexes); 1.3.2 Binding and uptake; 1.3.2.1 Phagocytosis; 1.3.2.2 Clathrin-mediated endocytosis; 1.3.2.3 Caveolae-mediated endocytosis; 1.3.2.4 Macropinocytosis; 1.3.2.5 Non-endocytic pathways; 1.3.3 Characteristics of non-viral gene delivery influencing uptake pathways; 1.3.3.1 Size; 1.3.3.2 Surface charge; 1.3.3.3 Shape; 1.3.3.4 Cell type
  • 1.3.4 Endosomal escape and dissociation of complexes1.3.4.1 Lipoplexes; 1.3.4.2 Polyplexes; 1.3.5 Fate in cytoplasm and nuclear entry; 1.4 Conclusion and future perspective; References; Chapter 2: PEI and its derivatives for gene therapy; 2.1 Introduction; 2.2 Criteria for non-viral vectors and general considerations; 2.3 Rationale for the use of PEI for gene therapy; 2.4 PEI Derivatives for gene delivery; 2.4.1 Grafting targeting ligands on PEI; 2.4.2 Chemical modification to shield cationic charge density; 2.4.3 Hydrophobic modifications; 2.4.4 Stimuli-sensitive construct
  • 2.4.4.1 Redox-sensitive construct2.4.5 pH-sensitive PEI constructs; 2.4.6 Temperature-sensitive PEI constructs; 2.5 PEGylation of PEI; 2.6 Polyester conjugation on PEI; 2.7 Chitosan conjugation on PEI; 2.8 PLL conjugation on PEI; 2.9 Metallic nanoparticles with PEIs; 2.10 Pharmacokinetics and bio-distribution of PEI delivery vectors; 2.11 Concluding remarks; Acknowledgements; References; Chapter 3: Natural polymers in nucleic acid delivery; 3.1 Introducing cells to exogenous nucleic acids; 3.1.1 Nucleic acids as therapeutics; 3.1.2 Applications in cancer
Control code
934626627
Dimensions
unknown
Extent
1 online resource.
File format
unknown
Form of item
online
Isbn
9780081005217
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
http://library.link/vocab/ext/overdrive/overdriveId
887354
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)934626627

Library Locations

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      400 West 14th Street, Rolla, MO, 65409, US
      37.955220 -91.772210
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