The Resource Polymers and nanomaterials for gene therapy, edited by Ravin Narain
Polymers and nanomaterials for gene therapy, edited by Ravin Narain
Resource Information
The item Polymers and nanomaterials for gene therapy, edited by Ravin Narain represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.This item is available to borrow from 1 library branch.
Resource Information
The item Polymers and nanomaterials for gene therapy, edited by Ravin Narain represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.
This item is available to borrow from 1 library branch.
- Summary
- Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy
- Language
- eng
- Extent
- 1 online resource.
- Contents
-
- PrefaceChapter 1: Mechanism, current challenges and new approaches for non viral gene delivery; 1.1 Introduction; 1.2 Current non-viral gene delivery vectors; 1.2.1 Naked DNA; 1.2.2 Cationic lipids; 1.2.2.1 Liposomes; 1.2.2.2 Lipid-coated DNA complexes; 1.2.2.3 Niosomes; 1.2.3 Cationic polymers; 1.2.3.1 Polyethylenimine (PEI); 1.2.3.2 Poly-L-lysine (PLL); 1.2.3.3 Polymethacrylate; 1.2.3.4 Chitosan; 1.2.3.5 Dendrimers; 1.2.3.5.1 Polyamidoamine dendrimers (PAMAM); 1.2.3.5.2 Poly(propylenimine) dendrimers (PPI); 1.2.3.5.3 Poly(L-lysine) dendrimers
- 1.3 Trajectory and mechanism of non-viral vectors1.3.1 Basics of non-viral gene delivery system formulation; 1.3.1.1 Complexes between cationic lipid and DNA (lipoplexes); 1.3.1.2 Complexes between cationic polymer and DNA (polyplexes); 1.3.2 Binding and uptake; 1.3.2.1 Phagocytosis; 1.3.2.2 Clathrin-mediated endocytosis; 1.3.2.3 Caveolae-mediated endocytosis; 1.3.2.4 Macropinocytosis; 1.3.2.5 Non-endocytic pathways; 1.3.3 Characteristics of non-viral gene delivery influencing uptake pathways; 1.3.3.1 Size; 1.3.3.2 Surface charge; 1.3.3.3 Shape; 1.3.3.4 Cell type
- 1.3.4 Endosomal escape and dissociation of complexes1.3.4.1 Lipoplexes; 1.3.4.2 Polyplexes; 1.3.5 Fate in cytoplasm and nuclear entry; 1.4 Conclusion and future perspective; References; Chapter 2: PEI and its derivatives for gene therapy; 2.1 Introduction; 2.2 Criteria for non-viral vectors and general considerations; 2.3 Rationale for the use of PEI for gene therapy; 2.4 PEI Derivatives for gene delivery; 2.4.1 Grafting targeting ligands on PEI; 2.4.2 Chemical modification to shield cationic charge density; 2.4.3 Hydrophobic modifications; 2.4.4 Stimuli-sensitive construct
- 2.4.4.1 Redox-sensitive construct2.4.5 pH-sensitive PEI constructs; 2.4.6 Temperature-sensitive PEI constructs; 2.5 PEGylation of PEI; 2.6 Polyester conjugation on PEI; 2.7 Chitosan conjugation on PEI; 2.8 PLL conjugation on PEI; 2.9 Metallic nanoparticles with PEIs; 2.10 Pharmacokinetics and bio-distribution of PEI delivery vectors; 2.11 Concluding remarks; Acknowledgements; References; Chapter 3: Natural polymers in nucleic acid delivery; 3.1 Introducing cells to exogenous nucleic acids; 3.1.1 Nucleic acids as therapeutics; 3.1.2 Applications in cancer
- Isbn
- 9780081005217
- Label
- Polymers and nanomaterials for gene therapy
- Title
- Polymers and nanomaterials for gene therapy
- Statement of responsibility
- edited by Ravin Narain
- Subject
-
- Polymers in medicine
- Electronic books
- Gene therapy
- Gene therapy
- HEALTH & FITNESS / Holism
- HEALTH & FITNESS / Reference
- MEDICAL / Alternative Medicine
- MEDICAL / Atlases
- MEDICAL / Essays
- MEDICAL / Family & General Practice
- MEDICAL / Holistic Medicine
- MEDICAL / Osteopathy
- Nanomedicine
- Nanomedicine
- Polymers in medicine
- Language
- eng
- Summary
- Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy
- Cataloging source
- N$T
- Dewey number
- 610.28
- Index
- index present
- LC call number
- R857.P6
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- http://library.link/vocab/relatedWorkOrContributorName
- Narain, Ravin
- Series statement
- Woodhead publishing series in biomedicine
- Series volume
- numbers 83
- http://library.link/vocab/subjectName
-
- Polymers in medicine
- Nanomedicine
- Gene therapy
- HEALTH & FITNESS / Holism
- HEALTH & FITNESS / Reference
- MEDICAL / Alternative Medicine
- MEDICAL / Atlases
- MEDICAL / Essays
- MEDICAL / Family & General Practice
- MEDICAL / Holistic Medicine
- MEDICAL / Osteopathy
- Gene therapy
- Nanomedicine
- Polymers in medicine
- Label
- Polymers and nanomaterials for gene therapy, edited by Ravin Narain
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- PrefaceChapter 1: Mechanism, current challenges and new approaches for non viral gene delivery; 1.1 Introduction; 1.2 Current non-viral gene delivery vectors; 1.2.1 Naked DNA; 1.2.2 Cationic lipids; 1.2.2.1 Liposomes; 1.2.2.2 Lipid-coated DNA complexes; 1.2.2.3 Niosomes; 1.2.3 Cationic polymers; 1.2.3.1 Polyethylenimine (PEI); 1.2.3.2 Poly-L-lysine (PLL); 1.2.3.3 Polymethacrylate; 1.2.3.4 Chitosan; 1.2.3.5 Dendrimers; 1.2.3.5.1 Polyamidoamine dendrimers (PAMAM); 1.2.3.5.2 Poly(propylenimine) dendrimers (PPI); 1.2.3.5.3 Poly(L-lysine) dendrimers
- 1.3 Trajectory and mechanism of non-viral vectors1.3.1 Basics of non-viral gene delivery system formulation; 1.3.1.1 Complexes between cationic lipid and DNA (lipoplexes); 1.3.1.2 Complexes between cationic polymer and DNA (polyplexes); 1.3.2 Binding and uptake; 1.3.2.1 Phagocytosis; 1.3.2.2 Clathrin-mediated endocytosis; 1.3.2.3 Caveolae-mediated endocytosis; 1.3.2.4 Macropinocytosis; 1.3.2.5 Non-endocytic pathways; 1.3.3 Characteristics of non-viral gene delivery influencing uptake pathways; 1.3.3.1 Size; 1.3.3.2 Surface charge; 1.3.3.3 Shape; 1.3.3.4 Cell type
- 1.3.4 Endosomal escape and dissociation of complexes1.3.4.1 Lipoplexes; 1.3.4.2 Polyplexes; 1.3.5 Fate in cytoplasm and nuclear entry; 1.4 Conclusion and future perspective; References; Chapter 2: PEI and its derivatives for gene therapy; 2.1 Introduction; 2.2 Criteria for non-viral vectors and general considerations; 2.3 Rationale for the use of PEI for gene therapy; 2.4 PEI Derivatives for gene delivery; 2.4.1 Grafting targeting ligands on PEI; 2.4.2 Chemical modification to shield cationic charge density; 2.4.3 Hydrophobic modifications; 2.4.4 Stimuli-sensitive construct
- 2.4.4.1 Redox-sensitive construct2.4.5 pH-sensitive PEI constructs; 2.4.6 Temperature-sensitive PEI constructs; 2.5 PEGylation of PEI; 2.6 Polyester conjugation on PEI; 2.7 Chitosan conjugation on PEI; 2.8 PLL conjugation on PEI; 2.9 Metallic nanoparticles with PEIs; 2.10 Pharmacokinetics and bio-distribution of PEI delivery vectors; 2.11 Concluding remarks; Acknowledgements; References; Chapter 3: Natural polymers in nucleic acid delivery; 3.1 Introducing cells to exogenous nucleic acids; 3.1.1 Nucleic acids as therapeutics; 3.1.2 Applications in cancer
- Control code
- 934626627
- Dimensions
- unknown
- Extent
- 1 online resource.
- File format
- unknown
- Form of item
- online
- Isbn
- 9780081005217
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- http://library.link/vocab/ext/overdrive/overdriveId
- 887354
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)934626627
- Label
- Polymers and nanomaterials for gene therapy, edited by Ravin Narain
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- PrefaceChapter 1: Mechanism, current challenges and new approaches for non viral gene delivery; 1.1 Introduction; 1.2 Current non-viral gene delivery vectors; 1.2.1 Naked DNA; 1.2.2 Cationic lipids; 1.2.2.1 Liposomes; 1.2.2.2 Lipid-coated DNA complexes; 1.2.2.3 Niosomes; 1.2.3 Cationic polymers; 1.2.3.1 Polyethylenimine (PEI); 1.2.3.2 Poly-L-lysine (PLL); 1.2.3.3 Polymethacrylate; 1.2.3.4 Chitosan; 1.2.3.5 Dendrimers; 1.2.3.5.1 Polyamidoamine dendrimers (PAMAM); 1.2.3.5.2 Poly(propylenimine) dendrimers (PPI); 1.2.3.5.3 Poly(L-lysine) dendrimers
- 1.3 Trajectory and mechanism of non-viral vectors1.3.1 Basics of non-viral gene delivery system formulation; 1.3.1.1 Complexes between cationic lipid and DNA (lipoplexes); 1.3.1.2 Complexes between cationic polymer and DNA (polyplexes); 1.3.2 Binding and uptake; 1.3.2.1 Phagocytosis; 1.3.2.2 Clathrin-mediated endocytosis; 1.3.2.3 Caveolae-mediated endocytosis; 1.3.2.4 Macropinocytosis; 1.3.2.5 Non-endocytic pathways; 1.3.3 Characteristics of non-viral gene delivery influencing uptake pathways; 1.3.3.1 Size; 1.3.3.2 Surface charge; 1.3.3.3 Shape; 1.3.3.4 Cell type
- 1.3.4 Endosomal escape and dissociation of complexes1.3.4.1 Lipoplexes; 1.3.4.2 Polyplexes; 1.3.5 Fate in cytoplasm and nuclear entry; 1.4 Conclusion and future perspective; References; Chapter 2: PEI and its derivatives for gene therapy; 2.1 Introduction; 2.2 Criteria for non-viral vectors and general considerations; 2.3 Rationale for the use of PEI for gene therapy; 2.4 PEI Derivatives for gene delivery; 2.4.1 Grafting targeting ligands on PEI; 2.4.2 Chemical modification to shield cationic charge density; 2.4.3 Hydrophobic modifications; 2.4.4 Stimuli-sensitive construct
- 2.4.4.1 Redox-sensitive construct2.4.5 pH-sensitive PEI constructs; 2.4.6 Temperature-sensitive PEI constructs; 2.5 PEGylation of PEI; 2.6 Polyester conjugation on PEI; 2.7 Chitosan conjugation on PEI; 2.8 PLL conjugation on PEI; 2.9 Metallic nanoparticles with PEIs; 2.10 Pharmacokinetics and bio-distribution of PEI delivery vectors; 2.11 Concluding remarks; Acknowledgements; References; Chapter 3: Natural polymers in nucleic acid delivery; 3.1 Introducing cells to exogenous nucleic acids; 3.1.1 Nucleic acids as therapeutics; 3.1.2 Applications in cancer
- Control code
- 934626627
- Dimensions
- unknown
- Extent
- 1 online resource.
- File format
- unknown
- Form of item
- online
- Isbn
- 9780081005217
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- http://library.link/vocab/ext/overdrive/overdriveId
- 887354
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)934626627
Subject
- Polymers in medicine
- Electronic books
- Gene therapy
- Gene therapy
- HEALTH & FITNESS / Holism
- HEALTH & FITNESS / Reference
- MEDICAL / Alternative Medicine
- MEDICAL / Atlases
- MEDICAL / Essays
- MEDICAL / Family & General Practice
- MEDICAL / Holistic Medicine
- MEDICAL / Osteopathy
- Nanomedicine
- Nanomedicine
- Polymers in medicine
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.mst.edu/portal/Polymers-and-nanomaterials-for-gene-therapy/NfMStPNtKB0/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.mst.edu/portal/Polymers-and-nanomaterials-for-gene-therapy/NfMStPNtKB0/">Polymers and nanomaterials for gene therapy, edited by Ravin Narain</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.mst.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.mst.edu/">Missouri University of Science & Technology Library</a></span></span></span></span></div>
