Coverart for item
The Resource Protein-protein interactions in drug discovery, edited by Alexander Dömling

Protein-protein interactions in drug discovery, edited by Alexander Dömling

Label
Protein-protein interactions in drug discovery
Title
Protein-protein interactions in drug discovery
Statement of responsibility
edited by Alexander Dömling
Contributor
Subject
Language
eng
Summary
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation. The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing medicinal chemist, this ready reference includes a wide selection of case studies taken straight from the devel
Member of
Cataloging source
E7B
Dewey number
615.19
Illustrations
illustrations
Index
index present
LC call number
QP551.5
LC item number
.P76 2013eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • W1
  • QU 55
NLM item number
ME961EH v.56 2013
http://library.link/vocab/relatedWorkOrContributorName
Dömling, Alexander
Series statement
Methods and principles in medicinal chemistry
Series volume
v. 56
http://library.link/vocab/subjectName
  • Protein-protein interactions
  • Protein binding
  • Proteins
  • Carrier Proteins
  • Drug Discovery
  • Protein Interaction Domains and Motifs
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • MEDICAL
  • Protein binding
  • Protein-protein interactions
Label
Protein-protein interactions in drug discovery, edited by Alexander Dömling
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Protein-protein interactions: an vverview / Christian Ottman -- Prediction of intra- and interspecies protein-protein interactions facilitating systems biology studies / Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K Ganapathiraju -- Modulators of protein-protein interactions: importance of three-dimensionality / David C Fry, Sung-Sau So -- A leap into the chemical space of protein-protein interaction inhibitors / Bruno O Villoutreix, C Labbé, David Lagorce, Guillaume Laconde, Olivier Sperandio -- Interactive technologies for leveraging the known chemistry of anchor residues to disrupt protein interactions / Carlos J Camacho, David R Koes, Alexander S Dömling -- SH3 domains as drug targets / James Luccarelli, Sam Thompson, Andrew D Hamilton -- p53/MDM2 antagonists: towards nongenotoxic anticancer treatments / Kareem Khoury, Tad A Holak, Alexander Dömling -- Inhibition of LFA-1/ICAM interaction for the treatment of autoimmune diseases / Kevin M Guckian, Daniel M Scott -- The PIF pocket of AGC kinases: a target site for allosteric modulators and protein-protein interaction inhibitors / Matthias Engel -- Retosiban and epelsiban: potent and selective orally available oxytocin antagonists / Alan D Borthwick, John Liddle -- Peptidic inhibitors of protein-protein interactions for cell adhesion receptors: RGD peptides and beyond / Carlos Mas-Moruno, Horst Kessler -- REPLACE strategy for generating non-ATP-competitive inhibitors of cell cycle protein kinases / Campbell McInnes -- Index
Control code
828743731
Dimensions
unknown
Extent
1 online resource (xxi, 314 pages)
Form of item
online
Isbn
9783527648238
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)828743731
Label
Protein-protein interactions in drug discovery, edited by Alexander Dömling
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Protein-protein interactions: an vverview / Christian Ottman -- Prediction of intra- and interspecies protein-protein interactions facilitating systems biology studies / Sylvia Schleker, Seshan Ananthasubramanian, Judith Klein-Seetharaman, Madhavi K Ganapathiraju -- Modulators of protein-protein interactions: importance of three-dimensionality / David C Fry, Sung-Sau So -- A leap into the chemical space of protein-protein interaction inhibitors / Bruno O Villoutreix, C Labbé, David Lagorce, Guillaume Laconde, Olivier Sperandio -- Interactive technologies for leveraging the known chemistry of anchor residues to disrupt protein interactions / Carlos J Camacho, David R Koes, Alexander S Dömling -- SH3 domains as drug targets / James Luccarelli, Sam Thompson, Andrew D Hamilton -- p53/MDM2 antagonists: towards nongenotoxic anticancer treatments / Kareem Khoury, Tad A Holak, Alexander Dömling -- Inhibition of LFA-1/ICAM interaction for the treatment of autoimmune diseases / Kevin M Guckian, Daniel M Scott -- The PIF pocket of AGC kinases: a target site for allosteric modulators and protein-protein interaction inhibitors / Matthias Engel -- Retosiban and epelsiban: potent and selective orally available oxytocin antagonists / Alan D Borthwick, John Liddle -- Peptidic inhibitors of protein-protein interactions for cell adhesion receptors: RGD peptides and beyond / Carlos Mas-Moruno, Horst Kessler -- REPLACE strategy for generating non-ATP-competitive inhibitors of cell cycle protein kinases / Campbell McInnes -- Index
Control code
828743731
Dimensions
unknown
Extent
1 online resource (xxi, 314 pages)
Form of item
online
Isbn
9783527648238
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Other physical details
illustrations
Specific material designation
remote
System control number
(OCoLC)828743731

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