The Resource Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)
Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)
Resource Information
The item Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.This item is available to borrow from all library branches.
Resource Information
The item Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource) represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.
This item is available to borrow from all library branches.
- Summary
- After spinal cord injury in larval lamprey, RS neurons regenerate their axons (Davis and McClellan, 1994a,b), restore synaptic contacts and most of the original locomotor functions (McClellan, 1998). It was previously demonstrated that calcium influx in RS neurons in culture results in inhibition of neurite outgrowth (Ryan et al., 2007). There is a hypothesis that injured RS neurons may undergo a number of changes in their electrical properties to maintain relatively low intracellular calcium concentrations and to promote axonal regeneration (Ryan et al., 2007; McClellan et al., 2008). For uninjured RS neurons, blocking calcium channels with various calcium channel blockers significantly reduced or eliminated the sAHP and produced changes in firing patterns in response to applied depolarizing current pulses that mimicked some of the effects of SCI. Furthermore, blocking SKKCa channels with apamin significantly reduced the sAHP compared to control values. However, blocking calcium and SKKCa channels in injured RS neurons did not have an apparent effect on sAHP and firing properties of the neurons. In addition, computer modeling shown that the AHP and firing properties of axotomized RS neurons could be obtained by substantially reducing calcium and SKKCa channel conductances compared to those in computer model of control RS neurons. This work provides additional information for understanding changes in ion channel expression in RS neurons that might be important to promote axonal regeneration in higher vertebrates, including humans
- Language
- eng
- Note
-
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Title from title screen of research.pdf file (viewed on August 12, 2009)
- Label
- Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey
- Title
- Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey
- Statement of responsibility
- by Mykola Kovalenko
- Language
- eng
- Summary
- After spinal cord injury in larval lamprey, RS neurons regenerate their axons (Davis and McClellan, 1994a,b), restore synaptic contacts and most of the original locomotor functions (McClellan, 1998). It was previously demonstrated that calcium influx in RS neurons in culture results in inhibition of neurite outgrowth (Ryan et al., 2007). There is a hypothesis that injured RS neurons may undergo a number of changes in their electrical properties to maintain relatively low intracellular calcium concentrations and to promote axonal regeneration (Ryan et al., 2007; McClellan et al., 2008). For uninjured RS neurons, blocking calcium channels with various calcium channel blockers significantly reduced or eliminated the sAHP and produced changes in firing patterns in response to applied depolarizing current pulses that mimicked some of the effects of SCI. Furthermore, blocking SKKCa channels with apamin significantly reduced the sAHP compared to control values. However, blocking calcium and SKKCa channels in injured RS neurons did not have an apparent effect on sAHP and firing properties of the neurons. In addition, computer modeling shown that the AHP and firing properties of axotomized RS neurons could be obtained by substantially reducing calcium and SKKCa channel conductances compared to those in computer model of control RS neurons. This work provides additional information for understanding changes in ion channel expression in RS neurons that might be important to promote axonal regeneration in higher vertebrates, including humans
- Cataloging source
- MUU
- http://library.link/vocab/creatorName
- Kovalenko, Mykola
- Degree
- M.A.
- Dissertation year
- 2008.
- Granting institution
- University of Missouri-Columbia
- Illustrations
- illustrations
- Index
- no index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- theses
- http://library.link/vocab/relatedWorkOrContributorName
- McClellan, Andrew
- http://library.link/vocab/subjectName
-
- Ion channels
- Spinal cord
- Nervous system
- Lampreys
- Target audience
- specialized
- Label
- Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)
- Note
-
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Title from title screen of research.pdf file (viewed on August 12, 2009)
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- mixed
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 430230224
- Dimensions
- unknown
- Form of item
- electronic
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)430230224
- System details
- Mode of access: World Wide Web
- Label
- Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)
- Note
-
- The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
- Title from title screen of research.pdf file (viewed on August 12, 2009)
- Bibliography note
- Includes bibliographical references
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- mixed
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Control code
- 430230224
- Dimensions
- unknown
- Form of item
- electronic
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Specific material designation
- remote
- System control number
- (OCoLC)430230224
- System details
- Mode of access: World Wide Web
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.mst.edu/portal/Spinal-cord-injury-induces-changes-in-ion/2HNSCZwcxWA/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.mst.edu/portal/Spinal-cord-injury-induces-changes-in-ion/2HNSCZwcxWA/">Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.mst.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.mst.edu/">Missouri University of Science & Technology Library</a></span></span></span></span></div>
