The Resource Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)

Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)

Label
Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey
Title
Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey
Statement of responsibility
by Mykola Kovalenko
Creator
Contributor
Thesis advisor
Subject
Genre
Language
eng
Summary
After spinal cord injury in larval lamprey, RS neurons regenerate their axons (Davis and McClellan, 1994a,b), restore synaptic contacts and most of the original locomotor functions (McClellan, 1998). It was previously demonstrated that calcium influx in RS neurons in culture results in inhibition of neurite outgrowth (Ryan et al., 2007). There is a hypothesis that injured RS neurons may undergo a number of changes in their electrical properties to maintain relatively low intracellular calcium concentrations and to promote axonal regeneration (Ryan et al., 2007; McClellan et al., 2008). For uninjured RS neurons, blocking calcium channels with various calcium channel blockers significantly reduced or eliminated the sAHP and produced changes in firing patterns in response to applied depolarizing current pulses that mimicked some of the effects of SCI. Furthermore, blocking SKKCa channels with apamin significantly reduced the sAHP compared to control values. However, blocking calcium and SKKCa channels in injured RS neurons did not have an apparent effect on sAHP and firing properties of the neurons. In addition, computer modeling shown that the AHP and firing properties of axotomized RS neurons could be obtained by substantially reducing calcium and SKKCa channel conductances compared to those in computer model of control RS neurons. This work provides additional information for understanding changes in ion channel expression in RS neurons that might be important to promote axonal regeneration in higher vertebrates, including humans
Cataloging source
MUU
http://library.link/vocab/creatorName
Kovalenko, Mykola
Degree
M.A.
Dissertation year
2008.
Granting institution
University of Missouri-Columbia
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • theses
http://library.link/vocab/relatedWorkOrContributorName
McClellan, Andrew
http://library.link/vocab/subjectName
  • Ion channels
  • Spinal cord
  • Nervous system
  • Lampreys
Target audience
specialized
Label
Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)
Instantiates
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on August 12, 2009)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
430230224
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)430230224
System details
Mode of access: World Wide Web
Label
Spinal cord injury induces changes in ion channels of reticulospinal neurons in larval lamprey, by Mykola Kovalenko, (electronic resource)
Publication
Note
  • The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file
  • Title from title screen of research.pdf file (viewed on August 12, 2009)
Bibliography note
Includes bibliographical references
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Control code
430230224
Dimensions
unknown
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Specific material designation
remote
System control number
(OCoLC)430230224
System details
Mode of access: World Wide Web

Library Locations

  • Curtis Laws Wilson LibraryBorrow it
    400 West 14th Street, Rolla, MO, 65409, US
    37.955220 -91.772210
  • Missouri University of Science & Technology Library DepositoryBorrow it
    2908 Lemone Blvd, Columbia, MO, 65201, US
    38.919360 -92.291620
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