The Resource Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma
Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma
Resource Information
The item Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.This item is available to borrow from 1 library branch.
Resource Information
The item Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Missouri University of Science & Technology Library.
This item is available to borrow from 1 library branch.
- Summary
- In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design.As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in
- Language
- eng
- Extent
- 1 online resource (476 pages)
- Contents
-
- Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases
- 2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors
- Isbn
- 9783527665211
- Label
- Structure-based design of drugs and other bioactive molecules : tools and strategies
- Title
- Structure-based design of drugs and other bioactive molecules
- Title remainder
- tools and strategies
- Statement of responsibility
- Arun K. Ghosh and Sandra Gemma
- Subject
-
- Bioactive compounds
- Bioactive compounds
- Biopolymers
- Biopolymers
- Biopolymers -- chemistry
- Drug Design
- Drug development
- Drug development
- Drugs -- Structure-activity relationships
- Drugs -- Structure-activity relationships
- Ligand binding (Biochemistry)
- Ligand binding (Biochemistry)
- MEDICAL -- Pharmacology
- Molecular Structure
- Protease Inhibitors -- chemistry
- Protease inhibitors
- Protease inhibitors
- Structure-Activity Relationship
- Electronic books
- Language
- eng
- Summary
- In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design.As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in
- Cataloging source
- EBLCP
- http://library.link/vocab/creatorName
- Ghosh, Arun K
- Dewey number
-
- 615.19
- 615/.19
- Index
- index present
- LC call number
- RS431.P38
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- NLM call number
-
- 2014 I-322
- QV 745
- http://library.link/vocab/relatedWorkOrContributorName
- Gemma, Sandra
- http://library.link/vocab/subjectName
-
- Drug development
- Bioactive compounds
- Biopolymers
- Ligand binding (Biochemistry)
- Protease inhibitors
- Drugs
- Drug Design
- Molecular Structure
- Biopolymers
- Protease Inhibitors
- Structure-Activity Relationship
- MEDICAL
- Bioactive compounds
- Biopolymers
- Drug development
- Drugs
- Ligand binding (Biochemistry)
- Protease inhibitors
- Label
- Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references at the end of each chapters and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases
- 2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors
- Control code
- 884646529
- Dimensions
- unknown
- Extent
- 1 online resource (476 pages)
- File format
- unknown
- Form of item
- online
- Isbn
- 9783527665211
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)884646529
- Label
- Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma
- Antecedent source
- unknown
- Bibliography note
- Includes bibliographical references at the end of each chapters and index
- Carrier category
- online resource
- Carrier category code
-
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
-
- txt
- Content type MARC source
- rdacontent
- Contents
-
- Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases
- 2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors
- Control code
- 884646529
- Dimensions
- unknown
- Extent
- 1 online resource (476 pages)
- File format
- unknown
- Form of item
- online
- Isbn
- 9783527665211
- Level of compression
- unknown
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
-
- c
- Quality assurance targets
- not applicable
- Reformatting quality
- unknown
- Sound
- unknown sound
- Specific material designation
- remote
- System control number
- (OCoLC)884646529
Subject
- Bioactive compounds
- Bioactive compounds
- Biopolymers
- Biopolymers
- Biopolymers -- chemistry
- Drug Design
- Drug development
- Drug development
- Drugs -- Structure-activity relationships
- Drugs -- Structure-activity relationships
- Ligand binding (Biochemistry)
- Ligand binding (Biochemistry)
- MEDICAL -- Pharmacology
- Molecular Structure
- Protease Inhibitors -- chemistry
- Protease inhibitors
- Protease inhibitors
- Structure-Activity Relationship
- Electronic books
Genre
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<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.library.mst.edu/portal/Structure-based-design-of-drugs-and-other/EsH7s6badno/" typeof="Book http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.library.mst.edu/portal/Structure-based-design-of-drugs-and-other/EsH7s6badno/">Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma</a></span> - <span property="potentialAction" typeOf="OrganizeAction"><span property="agent" typeof="LibrarySystem http://library.link/vocab/LibrarySystem" resource="http://link.library.mst.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.library.mst.edu/">Missouri University of Science & Technology Library</a></span></span></span></span></div>
