Coverart for item
The Resource Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma

Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma

Label
Structure-based design of drugs and other bioactive molecules : tools and strategies
Title
Structure-based design of drugs and other bioactive molecules
Title remainder
tools and strategies
Statement of responsibility
Arun K. Ghosh and Sandra Gemma
Creator
Contributor
Subject
Language
eng
Summary
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design.As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in
Member of
Cataloging source
EBLCP
http://library.link/vocab/creatorName
Ghosh, Arun K
Dewey number
  • 615.19
  • 615/.19
Index
index present
LC call number
RS431.P38
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
NLM call number
  • 2014 I-322
  • QV 745
http://library.link/vocab/relatedWorkOrContributorName
Gemma, Sandra
http://library.link/vocab/subjectName
  • Drug development
  • Bioactive compounds
  • Biopolymers
  • Ligand binding (Biochemistry)
  • Protease inhibitors
  • Drugs
  • Drug Design
  • Molecular Structure
  • Biopolymers
  • Protease Inhibitors
  • Structure-Activity Relationship
  • MEDICAL
  • Bioactive compounds
  • Biopolymers
  • Drug development
  • Drugs
  • Ligand binding (Biochemistry)
  • Protease inhibitors
Label
Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma
Instantiates
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases
  • 2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors
Control code
884646529
Dimensions
unknown
Extent
1 online resource (476 pages)
File format
unknown
Form of item
online
Isbn
9783527665211
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)884646529
Label
Structure-based design of drugs and other bioactive molecules : tools and strategies, Arun K. Ghosh and Sandra Gemma
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
  • cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
  • Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases
  • 2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors
Control code
884646529
Dimensions
unknown
Extent
1 online resource (476 pages)
File format
unknown
Form of item
online
Isbn
9783527665211
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
  • c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)884646529

Library Locations

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      400 West 14th Street, Rolla, MO, 65409, US
      37.955220 -91.772210
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